Oct 20, 2010 · The process of somite formation, or somitogenesis, depends on five important components: periodicity, fissure formation, epithelialization, specification, and differentiation. …

The cells within each somite are specified based on their location within the somite. Additionally, they retain the ability to become any kind of somite-derived structure until relatively late in the …

In humans, the first somite pair appears at day 20 and adds caudally at 1 somite pair/90 minutes until on average 44 pairs eventually form. A somite is added either side of the notochord (axial …

Alongside the neural tube, the mesoderm develops distinct paired structures called somites that develop into dermis, skeletal muscle, and vertebrae. Each somite has four compartments: the …

Jan 9, 1998 · The most distinct feature of vertebrate mesodermal segmentation is the somite. Indeed, cell fate in the immature somite is flexible and dependent on local environmental signals.

Apr 28, 2022 · Here, we report the generation of human somitoids, organoids that periodically form pairs of epithelial somite-like structures.

Using somitogenesis stage human embryos, we performed transcriptomic profiling of human presomitic mesoderm as well as nascent and developed somites. In addition to conserved …

Jun 9, 2025 · Somitogenesis is a complex and highly regulated process in developmental biology that involves the formation of somites, which are precursor structures that eventually give rise …

Somites are blocks of mesoderm cells that form in human embryos around 3 weeks after fertilization, with approximately 42-44 pairs developing. They play a crucial role in shaping the …

Feb 28, 2024 · Novel in vitro models of somitogenesis have provided insights into the spatiotemporal dynamics of gene expression, signalling and metabolic gradients that enable …