Protease mechanisms Protease mechanisms Polypeptides can be cleaved either chemically or enzymatically. Enzymes that catalyse the hydrolytic cleavage of peptide bonds are called proteases.

Nov 25, 2025 · Proteases articles from across Nature Portfolio Atom RSS Feed Proteases are enzymes that catalyse hydrolysis of the peptide and isopeptide bonds that join amino acids within proteins …

Oct 29, 2024 · Protease enzymes, in particular, have proven to be cost-effective, stable, and compatible alternatives to traditional chemical processes in both industrial and environmental applications.

Jul 1, 2025 · Substrate-specific proteases have an enormous potential in the life sciences, but tailoring their specificity remains challenging. Here, the authors describe a data-driven approach combining …

Aug 24, 2010 · The first serine protease scientists explored in detail was chymotrypsin, a digestive enzyme synthesized in our pancreas, along with the related enzymes trypsin and elastase.

Feb 25, 2025 · The bacterial Lon protease was recently identified as a potent inhibitor of human MYC, with effects on MYC-dependent gene expression and therapeutic efficacy in models of bladder and …

The status of human protease research and prospects for future protease-targeted drugs are reviewed here, with reference to some key examples where protease drugs have succeeded or failed.

Apr 22, 2025 · Structural and biochemical studies of the monkeypox virus core protease show that it exists as an active homodimer and indicate that the substrate-binding sites of core proteases are a …

Dec 30, 2024 · Instead of targeting a specific protease using a specific peptide substrate, we utilized an array of 360 FRET substrates to screen for cleavage patterns in plasma samples collected from …

Apr 16, 2025 · Our results suggest that this thermostable, alkaline, and detergent-biocompatible protease could be a promising additive for eco-friendly use in detergent industries.