Sans Microglia, Mice Develop CAA and Die Young - ALZFORUM
Jun 23, 2022 · Without microglia, endothelial integrity faltered, calcium crystals accumulated in the thalamus, and the blood vessels burst. Most animals died by 6 months old. Injecting microglia …
Human and Mouse Microglia Look Alike, but Age Differently
Jul 28, 2017 · But compared with profiles of aging mouse microglia (Grabert et al., 2016), the aging human microglia were starkly different—only 14 genes increased and only nine …
MS4A4A modifies the risk of Alzheimer disease by regulating lipid ...
Mar 10, 2023 · Michal Schwartz Weizmann Institute of Science Posted: 03 Mar 2023 News: Alzheimer’s Gene MS4A4A Governs the State of Microglia This manuscript provides a new …
A Unique Microglia Type Associated with Restricting ... - ALZFORUM
Jun 22, 2017 · There are points of real interest here, and it's potentially informative to take a step back and consider what's been detected using the elegant scRNA-Seq and computational …
Ferried Into Brain, TREM2 Antibody Stirs Microglia | ALZFORUM
Jan 23, 2023 · TREM2 signaling prompts microglia to move, proliferate, and engulf debris such as amyloid plaques. Previously, Haass' group had developed the anti-TREM2 mouse antibody …
Drivers for Common Microglial States Identified | ALZFORUM
Oct 22, 2025 · As readouts, they selected a marker for each of the most common microglial states: tetraspanin CD9 for DAM, interferon-induced protein IFIT1 for IRM, major …
AL002 - ALZFORUM
Nov 25, 2024 · Background This humanized monoclonal IgG1 antibody was being developed in a partnership between Alector and AbbVie. It binds the microglial receptor TREM2 and activates …
Human Microglia Mount Multipronged Response to AD Pathology
Oct 27, 2022 · Unlike the simple response of mouse microglia to amyloid plaques, human microglia react in diverse ways that researchers are just beginning to understand. Data from …
Hot DAM: Specific Microglia Engulf Plaques - ALZFORUM
Jun 22, 2017 · The current paper is a very elegant dissection and analysis of microglia subtypes, but there is no demonstration that the DAM microglia engulf plaques or restrict …
Long Live the Microglia! Studies Trace Their Lifespans in Mice and ...
Aug 30, 2017 · The researchers found that in wild-type mice, microglia died at a rate of about 26 percent per year, and an equal percentage of new ones formed. In an AD mouse model, …