Letrozole is an aromatase inhibitor used in the treatment of breast cancer. Aromatase inhibitors work by inhibiting the action of the enzyme aromatase, which converts androgens into …

Letrozole is recommended as the first-line medication for ovulation induction in polycystic ovary syndrome. Compared to clomiphene (Clomid), it causes higher number of ovulation and live …

Dec 1, 2022 · Letrozole is a powerful endocrine medication that targets and inhibits the aromatase, often known as an aromatase inhibitor (AI). It aids in the adjuvant, neoadjuvant, …

Mechanism of action. Letrozole acts locally on aromatase enzyme and blocks conversion of androgen to estrogen in ovarian follicle, peripheral tissue, and the brain.

Aug 19, 2024 · Letrozole belongs to a class of medicines called aromatase inhibitors. It works by blocking an enzyme called aromatase that helps produce estrogen in the body. By lowering …

Mechanism of Action: Letrozole effectively inhibits the aromatase enzyme, leading to decreased estrogen production, which is fundamental in hormone-sensitive cancers.

Nov 21, 2023 · Mechanism of action Letrozole, primarily used in the treatment of hormone-responsive breast cancer, functions as a potent inhibitor of aromatase, an enzyme that …

t effect on adrenal mineralocorticoid or glucocorticoid synthesis. Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme.

May 13, 2021 · Mechanism of Action: Decreases estrogen biosynthesis by selective competitive inhibition of aromatase in peripheral tissues (estrogen synthetase) Inhibition of aromatase …

Modern third-generation aromatase inhibitors (AIs) effectively block the production of estrogen without exerting effects on other steroidogenic pathways. The discovery of letrozole (Femara1) …