Apr 12, 2022 · Chronic obstructive pulmonary disease (COPD) is a deadly and highly morbid disease. Susceptibility to and heterogeneity of COPD are incompletely explained by environmental factors …

Abstract Background: In the UK, an estimated 15% of asthma patients have concurrent chronic obstructive pulmonary disease (COPD), yet the underlying causes and mechanisms remain largely …

Jul 21, 2025 · Background In the UK, an estimated 15% of asthma patients have concurrent chronic obstructive pulmonary disease (COPD), yet the underlying causes and mechanisms remain largely …

Mar 21, 2025 · We investigated the genetic susceptibility-associated lung function decline with or without COPD, using data from a community-based cohort (N = 8554).

Chronic obstructive pulmonary disease (COPD) is a complex disease influenced by both environmental and genetic factors. Through research performed largely in the past decade, the genetic basis of …

Genetic Factors in COPD Understanding the genetic factors associated with Chronic Obstructive Pulmonary Disease (COPD) is critical for a comprehensive grasp of this condition. Genetic …

The genetic determinants of COPD are likely composed of multiple genetic susceptibility variants of modest effect size and/or rare variants of large effect, acting in concert to create a diverse array of …

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease caused by the interaction of genetic susceptibility and environmental influences. There is increasing evidence that genes link to …

This study shows that genetic factors explain more than half of individual susceptibility to the lung function indi-ces FEV1, FVC, FEV1/FVC-ratio and half of the variance in airflow obstruction, chronic …

Mar 5, 2025 · Overall, our study underscored that tailored prevention in population groups with high genetic susceptibility would be more valuable and lead to a greater reduction in COPD incidence as …