Buffalo has looked much more comfortable playing in the snowy conditions, scoring three TDs in the first half on Sunday.

San Francisco 49ers fans held their collective breath Sunday when Christian McCaffrey went down with a non-contact injury in ...

Buffalo has run consistently over the previously perceived vaunted 49ers defense to jump up to a halftime lead.

San Francisco 49ers cornerback Renardo Green breaks up Buffalo Bills quarterback Josh Allen's improvised loft to Bills wide ...

San Francisco 49ers kicker Jake Moody's 33-yard field goal helps 49ers strike first on 'Sunday Night Football' against the ...

San Francisco 49ers running back Christian McCaffrey suffered another injury in just his fourth game of the season. During ...

After dealing with Achilles tendinitis for a majority of the season, running back Christian McCaffrey made his season debut ...

Christian McCaffrey pulled up limping after taking a pitch early in their game against the Bills on Sunday night.

Christian McCaffrey was off to a great start in Sunday night’s matchup with the Bills but had to exit the contest early in ...

San Francisco 49ers running back Christian McCaffrey suffered a knee injury and limped to the locker room in the second ...

San Francisco star running back Christian McCaffrey exited the 49ers Sunday Night Football game against the Bills with a knee ...

McCaffrey immediately checked himself out of the game and ran right into the medical tent. The 49ers star RB missed the ...