The San Francisco 49ers are reeling and now head to Buffalo for a prime time game. Will they have their starting QB back in ...

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

The 49ers have revealed their latest injury report before their Sunday Night Football tilt against the Buffalo Bills.

The Buffalo Bills will have to wait and see what happens with tight end Dalton Kincaid as his status for this week is up in ...

Around 10:50 p.m., Route 20A, also known as Big Tree Road, will convert to two-lane, one-way traffic eastbound away from the ...

Sunday could be the day Douglas has been waiting for -- because Milano is closing in on his return. The 30-year-old was a ...

Weather looks set to play a role in the Buffalo Bills' Week 13 matchup with the San Francisco 49ers.

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...

Following their bye week, the Bills (9-2) will take on the San Francisco 49ers (5-6) at Highmark Stadium in Week 13. But ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

There is a High Risk of Weather Impact (ROWI) for the NFL's Sunday Night Football matchup between the San Francisco 49ers ...

George Kittle will lead the San Francisco 49ers into their matchup versus the Buffalo Bills at Highmark Stadium on Sunday at ...