The Buffalo Bills dominated the San Francisco 49ers on Sunday night, winning 35-10 in Highmark Stadium in Orchard Park, N.Y.

ORCHARD PARK - Since the beginning of November, it was never a matter of if the Buffalo Bills would clinch the AFC East title ...

One week after a 38-10 road loss to the Green Bay Packers that stood out as one of their ugliest defeats in years, the San Francisco 49ers put on a performance against the Buffalo Bills at Highmark ...

Josh Allen scored a receiving touchdown on a pass he threw in his latest do-everything performance, and the Buffalo Bills ...

The Bills are just having fun in the snow in Orchard Park, with one of the more unique touchdowns you'll ever see giving the ...

The Buffalo Bills embrace the elements, possibly more than any other team in the NFL. Sure, the Packers and Steelers turn out ...

All eyes are on Highmark Stadium after 22.9 inches of lake-effect snow fell in Orchard Park ahead of the Sunday Night ...

As a steady lake-effect snowstorm pounded Orchard Park, the Bills did the same to the visiting San Francisco 49ers. Led on ...

San Francisco 49ers running back Christian McCaffrey suffered a knee injury and limped to the locker room in the second ...

Buffalo has looked much more comfortable playing in the snowy conditions, scoring three TDs in the first half on Sunday.

Heavy snowfall and numbing temperatures kept parts of the U.S. in a deep freeze Sunday as the Thanksgiving holiday ...

A lake effect snow event did little to deter Buffalo Bills fans eager to tailgate and watch the team play on Sunday.