Phosphorylation of tau makes its structure more flexible and allows it to form dynamic liquid droplets when temperature increases. Tau in this state can trigger intracellular tau to aggregate near ...

While much research related to Alzheimer’s disease has concentrated on identifying ways to reduce the buildup of amyloid plaques — which form when sticky protein fragments known as amyloid beta ...

To replicate the pathological changes in abnormal Tau phosphorylation, ready-to-use brain organoids (Cat. No. CIPO-BWL002K) were co-cultured with 100 µg/mL Tau PFFs (Cat. No. TAU-H5113).

To confirm the significance of tyrosine 29 phosphorylation in the development of NFTs, mice received mRNA via infection with a viral vector, encoding either a pathogenic tau variant or a double mutant ...

Specific pathways of Alzheimer's disease and FTLD-non-tau (FTLD-TDP linked to PGRN mutations) merge at tau phosphorylation. The mislocalization of phosphorylated tau to dendritic spines ...

Researchers have used an experimental drug to slow the phosphorylation of tau, which causes it to aggregate into neuron-damaging tangles in Alzheimer's disease Depositphotos View 1 Images ...

But research links tau phosphorylation and buildup in the brain to dementia, particularly Alzheimer’s disease. Doctors often measure tau levels when diagnosing Alzheimer’s.

Source Reference: Islam T, et al "Phospho-tau serine-262 and serine-356 as biomarkers of pre-tangle soluble tau assemblies in Alzheimer's disease" Nat Med 2025; DOI: 10.1038/s41591-024-03400-0.

Nonetheless, the study’s findings suggest that tau phosphorylation isn’t inherently harmful. Indeed, during brain development, it’s vital.

Conventional small-molecule drugs for reducing pTau include phosphatase activators of PP2A, and kinase inhibitors of GSK3β, CDK5, etc., as well as active or passive immunotherapies targeting pTau ...