Traditionally, the diagnosis of Alzheimer’s disease has been based on informant interviews and clinical assessments of memory, cognition, behaviour, and mood. To increase diagnostic confidence, ...

This graphene foam biosensor offers high sensitivity for tau protein detection, enabling early Alzheimer's diagnosis and potential clinical applications.

"The presentation of brain-derived pTau data at AAIC is a testament to the power of the NULISA sensitivity and specificity ...

New program combines IV-delivered TRACER™ capsid with bifunctional payload to silence APOE in carriers of the high-risk APOE4 ...

Learn the crucial role that tau proteins are playing for research into neurodegenerative diseases.

Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are both closely related sporadic parkinsonian disorders with tau pathology that share many clinical features, such as ...

Strikingly, people with ALS had far more of both p-tau isoforms in muscle fibers that showed signs of atrophy than in fibers that still appeared healthy. Moreover, their serum p-tau correlated with ...

The team focused on different versions of the tau protein, called isoforms, to see which one causes the most harm. They found that one specific form, known as 1N4R tau, is particularly toxic.

A research team at the University of Cologne has made a significant breakthrough in understanding the role of the tau protein in Alzheimer's disease. Using human induced pluripotent stem cells (iPSCs) ...

Article Title The tau isoform 1N4R confers vulnerability of MAPT knockout human iPSC-derived neurons to amyloid beta and phosphorylated tau-induced neuronal dysfunction ...

In this perspective, after a brief discussion about tau protein and the classic tau-targeting approaches, we will discuss the different classes of proximity-inducing modulators developed so far and ...