Amyloid-beta accumulation in centenarians negatively affected cognitive performance, which is consistent with the amyloid-cascade hypothesis. Accumulation of amyloid-beta pathology should not be ...

Neither experimental early-onset mutations nor late-onset clinical trials support Cassava Sciences’ hypothesis - amyloid-beta being a causal factor for Alzheimer’s.

The amyloid hypothesis— beta-amyloid is the cause of AD has been the conventional wisdom. Thus, developing drugs to target beta-amyloid has been the holy grail for more than a quarter of a century.

Researchers discover how amyloid-β and tau pathologies interact to drive early neurophysiological changes and cognitive decline in older adults at risk of Alzheimer’s disease.

Growing research shows common herpes viruses may raise dementia risk, challenging previous skepticism and opening new paths ...

“ [Autoimmune disease] includes [amyloid beta] as an important molecular player, but rejects the “amyloid hypothesis,” recognizing [amyloid beta] as a physiologically oligomerizing cytokine ...

The purity of Human Tau-441 (241-380), His Tag (Cat. No. TAU-H51H4) is greater than 95% verified by SDS-PAGE and more than 90% verified by SEC-MALS. Image Credit: ACROBiosystems ...

Even so, Bateman and many other scientists think it's too soon to abandon the amyloid hypothesis. "Penicillin, a great breakthrough, failed its first two clinical trials," Bateman says.

An idea that has propelled Alzheimer's research for more than 30 years is approaching its day of reckoning. Scientists are launching a study designed to make or break the hypothesis that Alzheimer's ...