Week 13 in the NFL is well underway with four games already under our belts over the Thanksgiving and Black Friday holiday. Now, it's time to heat up the leftovers and gear up for a jam-packed Sunday slate where we have a number of key matchups with major playoff implications.

Before looking at SportsbookWire staff's Week 13 NFL picks, here are the against-the-spread (ATS) and Over/Under (O/U) leaders, according to Teamrankings.com. The Detroit Lions (10-1 straight up) head into their Thanksgiving home game vs.

The Los Angeles Rams will try to bounce back from Sunday’s loss to the Philadelphia Eagles when they visit the New Orleans Saints this weekend. The Saints are riding a two-game winning streak and are coming off a Week 12 bye,

Aaron Rodgers and the New York Jets have lost seven of their last eight games and now will host the Seattle Seahawks for a cross-conference matchup in Week 13. The Seahawks have won five straight against the Jets and Seattle is a two-point favorite according to the latest Week 13 NFL odds.

The Indianapolis Colts visit the New England Patriots in NFL Week 13 action, both seeking to reverse recent trends.

NFL Week 13 picks, predictions, win probabilities for Chargers vs Falcons, Steelers vs Bengals, Eagles vs Ravens, 49ers vs Bills, this week's games.

There were mixed results in Week 12 of the NFL season. Half of the writers finished profitable on the week and there was a significant difference between the be

SportsLine's advanced model has locked in its Week 13 NFL betting picks and football predictions from 10,000 simulations to tell you how to bet NFL games

Thanksgiving week is one of the best times in the NFL calendar, and there are plenty of servings to go around the holiday weekend this season. All NFL teams will be in action in Week 13 with games taking place on four days.