The San Francisco 49ers were among the Super Bowl favorites heading into the season, but they find themselves below the .500 mark heading into their matchup against Buffalo during the Week 13 NFL schedule.

Thanksgiving means football and all 32 teams will be in action this week a full course of 11 games on Sunday. Sunday afternoon's action will be highlighted by the 4:25 p.m. ET matchup between the Philadelphia Eagles and Baltimore Ravens,

NFL Week 13 betting spreads, lines, point totals for every game on NFL Week 13 schedule, with odds for favorites and underdogs in each NFL matchup.