Week 13 in the NFL is well underway with four games already under our belts over the Thanksgiving and Black Friday holiday. Now, it's time to heat up the leftovers and gear up for a jam-packed Sunday slate where we have a number of key matchups with major playoff implications.

The Colts are 4-1 against teams with a losing record. Our expert NFL predictions expect Jonathan Taylor to lead the Colts to victory.

Week 12 of the 2024-25 NFL season features seven divisional matchups, multiple games with double-digit point spreads and the first “Harbaugh Bowl” in over a dozen years.