Two NFC West teams renew their rivalry as we continue our NFL odds series with a 49ers-Rams prediction and pick.

Pregame analysis and predictions of the San Francisco 49ers vs. Los Angeles Rams NFL game to be played on September 22, 2024 on ESPN.

The Rams have their work cut out for them in Week 3 but they have a chance to upset the 49ers if they win these 5 matchups

San Francisco 49ers quarterback Brock Purdy is still making quite an impact in the state of Iowa despite being three years removed from his playing days for the Cyclones. Purdy and the Niners will play in one of three games that will air on Fox during the later slate of games at 1 p.

San Francisco 49ers quarterback Brock Purdy isn't letting early-season injuries shake his confidence. Although he has been without reigning NFL Offensive Player of the Year Christian McCaffrey for the first two games—McCaffrey will miss at least the next three with Achilles tendinitis—Purdy remains optimistic.

In Purdy's last seven starts, he has won four games, lost three, thrown six touchdown passes and six interceptions, fumbled once and posted a passer rating of 87. That's about as average as it gets. And he's playing on the best team in football.

George Kittle could have to miss his first game of the season as the San Francisco 49ers take on the Los Angeles Rams on Sunday. Per ESPN's Adam

The San Francisco 49ers are facing another blow to their offense after star tight end George Kittle missed Thursday's practice with what ESPN and NFL Network reported to be hamstring