City, county and state officials are preparing for whatever the weather system has in store for Western New York.

The San Francisco 49ers are reeling and now head to Buffalo for a prime time game. Will they have their starting QB back in ...

Quarterback Tua Tagovailoa hopes to continue his hot streak in the cold when he and the Miami Dolphins visit Lambeau Field ...

Brock Purdy was listed as limited for Wednesday's practice by San Francisco 49ers head coach Kyle Shanahan, suggesting some ...

The Buffalo Bills are set to have a classic snow game matchup against the San Francisco 49ers in Orchard Park.

The San Francisco 49ers are preparing for their Week 13 contest against the Buffalo Bills on Sunday at Highmark Stadium in ...

LB Fred Warner, WR Deebo Samuel Sr., RB Christian McCaffrey and DL Nick Bosa identified key areas for improvement as the team ...

The banged-up San Francisco 49ers received some positive news on Wednesday. Per ESPN's Nick Wagoner, 49ers head coach Kyle ...

Every week, Thad Brown answers your questions live from Orchard Park about the Bills and their next game. This week, Buffalo ...

The 49ers have revealed their latest injury report before their Sunday Night Football tilt against the Buffalo Bills.

Traffic and road closure information for Sunday’s Buffalo Bills game against the San Francisco 49ers has been announced by ...

The Bills and 49ers meet on Sunday Night Football in a game with playoff implications for both teams. Here are three ...