Officials in upstate New York counties have declared a state of emergency as they prepare for a major snowstorm that has ...

The Buffalo Bills dominated the San Francisco 49ers on Sunday night, winning 35-10 in Highmark Stadium in Orchard Park, N.Y.

The 49ers had three fumbles in Sunday night's contest, all three of which were recovered by the Bills. San Francisco's ...

One week after a 38-10 road loss to the Green Bay Packers that stood out as one of their ugliest defeats in years, the San Francisco 49ers put on a performance against the Buffalo Bills at Highmark ...

Christian McCaffrey will not return to Sunday's matchup against the Bills. McCaffrey has been downgraded to out with the knee ...

Lake-effect snow is clobbering areas from the Great Lakes in Michigan to Buffalo, but hundreds of Bills fans grabbed shovels ...

The Buffalo Bills embrace the elements, possibly more than any other team in the NFL. Sure, the Packers and Steelers turn out ...

Buffalo Bills and San Francisco 49ers reveal game-day inactives as both teams prepare for winter wonderland matchup at ...

All eyes are on Highmark Stadium after 22.9 inches of lake-effect snow fell in Orchard Park ahead of the Sunday Night ...

Linebacker Matt Milano will return for the Buffalo Bills' Week 13 bout with the San Francisco 49ers, but wide receiver Keon ...

Cities across northern parts of lower Michigan and eastern Upper Michigan, will see lake effect snow through Monday night ...

Follow along for updates throughout the game as the Buffalo Bills take on the San Francisco 49ers at snowy Highmark Stadium.