The San Francisco 49ers placed running back Christian McCaffrey on injured reserve on Aug. 14 but have yet to fill his vacant ...

According to Tallysight, a whopping 96% of experts are picking the 49ers to beat the Rams. It’s slightly better when ...

Purdy still hasn't entirely shaken the "system" quarterback label and other denigrations. A chance for his rebuttal is now ...

Injuries already are accruing across the NFL, knocking several star players out and forcing teams to turn to backups and ...

Injuries stacked up quickly for the San Francisco 49ers leading up to their Week 3 showdown with the Los Angeles Rams.

The 49ers are partly to blame for why Christian McCaffrey will be out at least four games and possibly more as he nurses ...

Week 3 matchup vs. Rams with key injuries to McCaffrey, Samuel, and Kittle, testing their depth in this crucial NFC West ...

Injuries have caused many problems for the San Francisco 49ers this year, and now Brock Purdy has lost another offensive ...

Jamey Eisenberg believes injuries to key players have set the stage for a breakout performance by Brandon Aiyuk ...

The San Francisco 49ers could be without another key offensive player this week after All-Pro tight end George Kittle missed ...

The 49ers are without Christian McCaffrey, Deebo Samuel and maybe George Kittle, while the Rams won’t have top receivers ...