Buffalo Bills coach Sean McDermott looked and sounded refreshed as he and his team returned from its bye week.

The Bills can clinch the division in Week 13 if the Miami Dolphins lose to the Green Bay Packers at Lambeau Field on Thursday ...

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

Sunday could be the day Douglas has been waiting for -- because Milano is closing in on his return. The 30-year-old was a ...

The Buffalo Bills will have to wait and see what happens with tight end Dalton Kincaid as his status for this week is up in ...

The 49ers have revealed their latest injury report before their Sunday Night Football tilt against the Buffalo Bills.

Traffic and road closure information for Sunday’s Buffalo Bills game against the San Francisco 49ers has been announced by ...

San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...

The San Francisco 49ers may again be without starting quarterback Brock Purdy for their Week 13 clash with the San Francisco ...

Milano practiced without a red non-contact jersey for the first time since his bicep injury and was listed on the injury ...