Week 13 in the NFL is well underway with four games already under our belts over the Thanksgiving and Black Friday holiday. Now, it's time to heat up the leftovers and gear up for a jam-packed Sunday slate where we have a number of key matchups with major playoff implications.

One fascinating matchup to watch for is wideout Courtland Sutton against cornerback Denzel Ward. The latter leads football with 17 passes deflected. And Sutton is enjoying his best season since his 2019 Pro Bowl campaign. He’s capable of acrobatic, catch-of-the-year grabs on any drive.

NFL Week 13 picks, predictions, win probabilities for Chargers vs Falcons, Steelers vs Bengals, Eagles vs Ravens, 49ers vs Bills, this week's games.

SportsLine's advanced model has locked in its Week 13 NFL betting picks and football predictions from 10,000 simulations to tell you how to bet NFL games

In Sporting News' latest weekly game picks and predictions against the spread for Week 13, the Bills keep the 49ers reeling, while the Vikings down the Cardinals and the Seahawks ground the Jets.

Betting against the Tennessee Titans has been a profitable NFL betting strategy this season. Tennessee is 2-9 against the spread, but the Titans are coming off an impressive victory on the road against the Houston Texans as 7.