San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got ...

San Francisco 49ers linebacker Fred Warner says he has been playing through a fractured bone in his ankle since Week 4.

We thought San Francisco was poised for a massive second-half run after the Week 9 bye with Christian McCaffrey back, but the ...

The San Francisco 49ers are 5-6 entering their matchup with the Buffalo Bills on Sunday, and an NFL executive called out ...

San Francisco 49ers running back Christian McCaffrey is three games into his return from injury. The two-time first-team ...

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...

Brock Purdy threw one short pass in the open portion of practice for the San Francisco 49ers as he remains slowed by an ...

Former Buffalo Bills defensive end Leonard Floyd spoke about facing his old team on Sunday night with the San Francisco 49ers ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

The San Francisco 49ers are reeling and now head to Buffalo for a prime time game. Will they have their starting QB back in ...

The 49ers happened to have room at quarterback amid Brock Purdy's injury. Kyle Shanahan revealed if Daniel Jones was a ...

San Francisco 49ers head coach Kyle Shanahan told reporters that star quarterback Brock Purdy will practice with the team ...