AFC meets NFC in an in-state 2025 NFL preseason battle as the Buffalo Bills host the New York Giants on Saturday. The Bills topped the AFC East last season with a 13-4 record, and are looking to have another strong season before making a deeper playoff run.

The Bills are a much better team than the Giants, and while much of that is the star quarterback and difference makers on both sides of the ball, there’s another reason that becomes apparent quickly during preseason football. Good teams usually have better depth throughout their roster, giving them an advantage when it becomes backups vs. backups.

Get the best Giants vs. Bills predictions ahead of Saturday's preseason clash. Free NFL picks and predictions for August 9.