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The oocytes of the African clawed frog, Xenopus laevis, contain large numbers of nucleoli; the foundation for this phenomenon is the presence of numerous extrachromosomal copies of the genes ...

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This important paper describes a comprehensive quantitative phospho-proteomic analysis of the meiotic progression of Xenopus oocytes. Using time-resolved proteomic analyses, the authors provide ...

GLP-1 receptor (GLP-1R) and neuropeptide Y2 receptor (Y2R) dual agonists have shown great potential to treat obesity and type 2 diabetes (T2DM). We developed a multitarget strategy to design monomeric ...