The San Francisco 49ers and fantasy football players who were relying on the NFC West team's running backs are probably all ...

San Francisco 49ers offense. Scoring touchdowns in the red zone has been abysmal all season long for them and so has putti ...

The San Francisco 49ers have signed a former New York Jets running back to replace the injured Christian McCaffrey and Jordan ...

Ricky Pearsall Jr., the 49ers first-round draft pick, was shot through the chest on Aug. 31 in a robbery attempt.

Heartbreak has struck the 49ers family again with the news that the newborn son of left tackle Trent Williams died on Nov. 24 ...

The San Francisco 49ers will be without their top two running backs for the remainder of the regular season after the pair of ...

The San Francisco 49ers look ready to make Brock Purdy their QB of the future, but they may need to act fast to get it done ...

San Francisco 49ers running back Jordan Mason is going on injured reserve, head coach Kyle Shanahan announced.

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

The 49ers lost running back Christian McCaffrey for the season with a knee injury. His backup, Jordan Mason, will also be ...

Ten months after their wild-card playoff game against the Pittsburgh Steelers was postponed due to blizzard conditions, the ...

On a snowy night in Orchard Park, N.Y., the Buffalo Bills clinched the AFC East title with a dominant win over the San ...