gut.bmj3d
Immune checkpoint inhibitors and the liver: balancing therapeutic benefit and adverse events
Immune checkpoint inhibitors (ICI) have led to breakthrough improvements in the management of malignancy including hepatocellular (HCC) and biliary tract cancer, improving decades-old standards of ...
gut.bmj2d
Antiviral therapy for chronic hepatitis delta: new insights from clinical trials and real-life studies
Chronic hepatitis D (CHD) is the most severe form of viral hepatitis, carrying a greater risk of developing cirrhosis and its ...
gut.bmj17d
Integration of lipidomics with targeted, single cell, and spatial transcriptomics defines an unresolved pro-inflammatory state in colon cancer
Background Over a century ago, Virchow proposed that cancer represents a chronically inflamed, poorly healing wound. Normal wound healing is represented by a transitory phase of inflammation, followed ...
gut.bmj19h
The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans
a Department of Research and Division of Gastroenterology, University Hospital, CH-4031 Basel, Switzerland, b Rotta Research Laboratorium SpA, I-20052 Monza, Italy Dr Christoph Beglinger, Division of ...
gut.bmj1d
Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro
Objective: Persistent stress and life events affect the course of ulcerative colitis and irritable bowel syndrome by largely unknown mechanisms. Corticotropin-releasing hormone (CRH) has been ...
gut.bmj1d
Low socioeconomic class is a risk factor for upper and lower gastrointestinal symptoms: a population based study in 15 000 Australian adults
Department of Medicine, University of Sydney, Nepean Hospital, Penrith, Australia Dr N J Talley, Department of Medicine, University of Sydney, Nepean Hospital, Clinical Sciences Building, PO Box 63, ...
gut.bmj6d
Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans
Objective Increased de novo fatty acid (FA) synthesis and cholesterol biosynthesis have been independently described in many tumour types, including hepatocellular carcinoma (HCC). Conclusion Our ...
gut.bmj1d
Depression in individuals who subsequently develop inflammatory bowel disease: a population-based nested case–control study
Correspondence to Dr Richard C Pollok, Gastroenterology, St George's University Hospitals NHS Foundation Trust, London SW17 0QT, UK; richard.pollok{at}nhs.net Objective Depression is a potential risk ...
gut.bmj5d
Impairment of spermatogenesis and sperm motility by the high-fat diet-induced dysbiosis of gut microbes
Objective High-fat diet (HFD)-induced metabolic disorders can lead to impaired sperm production. We aim to investigate if HFD-induced gut microbiota dysbiosis can functionally influence ...
gut.bmj4d
Cigarette smoke promotes colorectal cancer through modulation of gut microbiota and related metabolites
Correspondence to Professor Jun Yu, Institute of Digestive Disease, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China; ...
gut.bmj2d
Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model
Correspondence to Professor Jin-Woo Bae, Department of Life and Nanopharmaceutical Sciences and Department of Biology, Kyung Hee University, Seoul 02447, Republic of Korea; baejw{at}khu.ac.kr; ...
gut.bmj3d
A simple clinical colitis activity index
a Inflammatory Bowel Disease Study Group, Royal Free Hospital School of Medicine, London, UK, b Gastroenterology Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK Dr R N Allan, Queen Elizabeth ...