More than 90% of people with Down syndrome (DS) are diagnosed with Alzheimer’s disease (AD) by ages 55–60. However, it remains unknown whether there is a difference in the structure of amyloid-β (Aβ) ...

As a prominent form of amyloid protein, tau aggregates have emerged as a primary focus of research for uncovering the mechanisms underlying neurodegeneration. Various types of tau aggregates, ...

For almost 10 years, scientists around the world have been using cell-based fluorescent sensors to study the protofibrils that spawn neurofibrillary tangles in tauopathies. Some have claimed the tau ...

A custom-designed electron cryomicroscope operating at 100 keV promises to minimize the expense and complexity of biological structure research. Although electron cryo-microscopy (cryo-EM) has shown ...

Cryo-electron microscopy (cryo-EM) has revolutionalized our understanding of the intricate molecular machinery that governs life. It has elucidated the three-dimensional (3D) structure of biological ...

WEST LAFAYETTE, Ind. — Purdue University experts in the College of Science and Rosen Center for Advanced Computing have launched Molecular Intelligence, a software company whose solutions help ...

Scientists at Northwestern University and University of California, Santa Barbara have created the first synthetic fragment of tau protein that acts like a prion. The “mini prion” folds and stacks ...

Solving the structure of an amyloid protein gives new insight into limb-girdle muscular dystrophy type 3 (LGMD D3) and functional protein aggregation. LGMD D3 is a rare disease characterized by slow ...