Tauopathies are classified into several groups based on the isoform composition of tau aggregates. The splicing of the gene encoding tau is regulated by multiple factors besides tau mutations.

In the adult human brain, tau exists in six isoforms, each with unique structural properties. These isoforms are produced through alternative splicing of the MAPT gene, with variations affecting ...

Using human induced pluripotent stem cells (iPSCs), researchers identified a specific form of tau, known as the 1N4R isoform, as a key driver of neuronal dysfunction in the presence of amyloid beta ...

Now a novel antibody technology developed by a scientific team at Beth Israel Deaconess Medical Center (BIDMC) provides the first clear distinction between two tau isoforms – one healthy and one ...

They homed in on a splice variant known as “big tau,” almost twice the size of the other isoforms, that is common in the peripheral nervous system. To their surprise, they found the behemoth in the ...

it contains 16 exons and alternative splicing allows six tau isoforms. Hyperphosphorylation of the tau protein can result in the self-assembly of intraneuronal tangles of tau filaments ...

Tau isoforms (0N3R, 0N4R, 1N3R, 1N4R, 2N3R, 2N4R) are categorized by amino-terminal exon inserts and carboxyl-terminal microtubule-binding domain (MBD) repeats. 6 The MBD’s repetition regions ...

One of their aims was to analyze the expression of isoforms of a protein called Tau, which is associated with neurodegenerative diseases such as Parkinson's. This makes Tau isoforms a potential ...

And in the December 20 issue of the journal Hippocampus, also online, Thomas Arendt and colleagues report that a specific isoform of tau previously thought to be expressed only during embryogenesis is ...