THE earliest lesions of certain types of experimental nephrocalcinosis involve the distal portions of the renal tubules and the collecting ducts. 1,2 Disturbances in renal tubular function might ...

In addition to regulating the body's fluid balance, by excreting greater or smaller amounts of urine, the kidneys also maintain the proper balance of electrolytes (salts) and the pH (an acid-base ...

The Journal of Cell Biology (JCB) is a not-for-profit publication, edited by scientists, and a leading life sciences journal. The JCB publishes papers on all aspects of cellular structure and function ...

Glucagon-sensitive adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] activity was measured in nine different portions of the rat nephron. Each sample contained a single piece of ...

Nat Clin Pract Nephrol. 2008;4(1):38-46. Our knowledge of the localization, function, physiology and pathophysiology of the kidney-specific Cl-channels and Barttin has been greatly extended in the ...

The kidney, a critical organ for waste filtration and fluid regulation, is the subject of a groundbreaking molecular mapping project that could reshape our understanding of renal health. Despite ...

Treatment of this condition differs from those described above. With its low levels of aldosterone, this condition is refractory to standard medical management aimed at reducing aldosterone levels. In ...

A right kidney stone as seen on abdominal CT Some risk factors are unavoidable, but adjusting your patient's diet and addressing comorbidities can prevent excruciating episodes. The time-honored ...

The presence and number of kidney cysts, particularly in the medulla, may be an additional imaging-based biomarker for progressive CKD after radical nephrectomy for kidney cancer. Among patients who ...