G-protein-coupled receptors (GPCRs) are among the most successful targets for drug discovery research. They represent the largest family of cell surface receptors with approximately 400 in the ...

Astrocyte activity precedes the onset of epileptic neuronal hyperactivity episodes. (A) With cytosolic calcium ion increase, excitatory actions from astrocytes to neurons are likely to be initiated.

Calcium signaling is essential for cellular communication, orchestrating a myriad of physiological processes. As the quest for a more profound understanding of cellular dynamics intensifies, calcium ...

Astrocytes are specialized glial cells ubiquitously distributed throughout the spinal cord and brain. They occupy approximately 50% of the total volume of the central nervous system (CNS) and are ...

Astrocytes are found throughout the brain. Each astrocyte is in contact with several neurons and more than 100'000 synapses. A new study shows that, at the microscopic level, dozens of synapses from ...