To rescue stalled ribosomes, bacteria use tmRNA (also known as 10Sa RNA), a ∼300-nucleotide-long molecule so-named for its dual tRNA-like and mRNA-like nature. Although the tmRNA structure is well ...

tmRNA contains an alanyl-tRNA–like domain (TLD) and an open reading frame (ORF) encoding a peptide degradation tag. During the rescue process, alanyl-tmRNA binds in the ribosome A site and ...

The tmRNA molecule is thus able to smuggle in the missing stop signal and lift the blockade. It was never exactly clear how this large tmRNA molecule moves through the ribosome and smuggles its ...

News & Views Published: May 1999 Transmutation of tRNA over time Jürgen Brosius Nature Genetics 22, 8–9 (1999) Cite this article ...