The ribosome, that protein-making machine, relies on other, smaller machines. For example, it works in concert with a mechanism that supplies amino-acid-carrying tRNAs, including tRNAs that require ...

The fruit fly lacks the tRNA nuclear export receptor Exportin-t, which only exports end-processed tRNAs to the cytoplasm to ensure the completion of the processing steps in the nucleus. The related ...

To build proteins, cells rely on a molecule called transfer RNA, or tRNA. tRNAs act like protein-building couriers, where they read the genetic instructions from messenger RNA, mRNA, and deliver the ...

Researchers have identified a novel brain disorder that is neurodegenerative, but so early onset that it disrupts development, leading to disturbances in the formation and function of hindbrain ...

A team of researchers from Mass General Brigham led by Raghu Chivukla, MD, PhD released a new study linking protein aggregation to altered RNA processing in genetic forms of neurodegeneration.

The tRNA3 Leu gene from yeast contains an intervening sequence of 32 nucleotides not present in mature tRNA. This sequence is transcribed and subsequently removed during the maturation of the RNA. To ...

Raghu R. Chivukula, MD, Ph.D., a physician-investigator in the Departments of Medicine & Surgery and the Center for Genomic Medicine at Massachusetts General Hospital and Harvard Medical School, is ...

I am a graduate student in Dr. Ashleigh Schaffer’s lab. Broadly, the lab seeks to understand molecular mechanisms of physiological and pathological neurodevelopment. In pursuing this goal, Dr.

HC Bioscience is shutting down after conducting preclinical models for a transfer RNA (tRNA) asset designed to treat hemophilia A. The Cambridge, Massachusetts-based biotech is closing “following ...

Researchers have identified a novel brain disorder that is neurodegenerative, but so early onset that it disrupts development, leading to disturbances in the formation and function of hindbrain ...