JSTOR Daily

Targeting stem-loop 1 of the SARS-CoV-2 5′ UTR to suppress viral translation and Nsp1 evasion

SARS-CoV-2 is a highly pathogenic virus that evades antiviral immunity by interfering with host protein synthesis, mRNA stability, and protein trafficking. The SARS-CoV-2 nonstructural protein 1 (Nsp1 ...
EurekAlert!

Mechanism of embryonic arrest caused by maternal mRNA decay failure and R-loop accumulation (IMAGE)

A mechanism by which knockouts of maternal mRNA clearing factors lead to zygotic arrest in mice. Abnormal accumulation of maternal mRNAs in mouse zygotes leads to transcriptional leakage before the ...
JSTOR Daily

Secondary structure of the mRNA encoding listeriolysin O is essential to establish the replicative niche of L. monocytogenes

Intracellular pathogens are responsible for an enormous amount of worldwide morbidity and mortality, and each has evolved specialized strategies to establish and maintain their replicative niche.
Phys.org

Molecular dynamics simulations use atomistic force field to capture RNA folding with high accuracy

Ribonucleic acid (RNA) is one of life's most versatile molecules, with roles going far beyond being a messenger of genetic code, as it is fundamentally involved in gene regulation, processing, and ...
Science Daily

Closing the RNA loop holds promise for more stable, effective RNA therapies

New methods to shape RNA molecules into circles could lead to more effective and long-lasting therapies, shows a new study. The advance holds promise for a range of diseases, offering a more enduring ...