The Bills sacked Purdy twice, Greg Rousseau getting one while the other was called a team sack because Purdy lost a fumble behind the line of scrimmage that was recovered by Rousseau. Damar Hamlin should have had an interception, but it was nullified by a ticky-tack holding call on Hamlin before he made the catch. It was a bad call.

As the snow continued to fall on Buffalo's Highmark Stadium, quarterback Josh Allen hit wide receiver Amari Cooper in the red zone on a quick slant. After being stifled by several San Francisco 49ers defenders, Cooper decided to give his quarterback a chance to shine, and lateraled it to him.

The Bills are coming off a bye week and riding a six-game winning streak behind MVP favorite Josh Allen, most recently beating the previously undefeated Chiefs two weeks ago. Tight end Dalton Kincaid is out with a knee injury and receiver Keon Coleman is questionable with a wrist injury.