New research finds an unexpected link between chromosomal instability and epigenetic alternations, both of which are hallmarks of cancer -- especially advanced, drug-resistant cancers. A graduate ...

Validation of large chromosomal segment deletions by chromosome painting. (a, b) FISH assays of the chr2 barcode probes and chr2 painting probes on metaphase chromosomes prepared from LeiTing. The ...

A study conducted by the Development and Growth Control Laboratory at IRB Barcelona sheds light on the contribution of DNA damage to the invasiveness of cancer cells. The discovery challenges the ...

Chromosomal instability is a phenomenon characterized by rapid changes in the number and structure of chromosomes during cell division. It is very common in solid tumors and it is linked to the ...

Like the plastic aglets at the ends of shoelaces, telomeres normally protect the ends of chromosomes from instability and degradation – the hallmarks of cancer. Johns Hopkins University researchers ...

Many tumors express meiotic genes that could potentially drive somatic chromosome instability. While germline cohesin subunits SMC1B, STAG3, and REC8 are widely expressed in many cancers, messenger ...