"Insulin binding to InsRα derepresses the tyrosine kinase activity of the β-subunit (InsRβ). This initiates a whole metabolic pathway with different steps that eventually allow glucose ...

The development of any tyrosine kinase inhibitor must be inextricably linked to a sound and meticulous understanding of the mechanisms of resistance associated with its use. The introduction of ...

1). The phosphorylation of the biotin-tagged generic peptide is initiated by the addition of ATP in the presence of the tyrosine kinase (step 1) and stopped by the addition of a mix containing the ...

More information: A 3-week pause versus continued Bruton tyrosine kinase inhibitor use during COVID-19 vaccination in individuals with chronic lymphocytic leukaemia (IMPROVE trial): a randomised, open ...

Panelists discuss how cardiovascular toxicity remains a significant concern with certain tyrosine kinase inhibitors (TKIs) used in chronic myeloid leukemia (CML) treatment, particularly with the older ...

who are being treated with Bruton Tyrosine Kinase inhibitors (BTKi), should continue their therapy while receiving COVID-19 vaccination. The IMPROVE study investigated whether a three-week pause ...