Our research involving the tyrosine kinase 2 (TYK2) pathway exemplifies our innovation, as we were able to overcome challenges regarding TYK2’s regulatory domain that, for decades, scientists ...

Bristol Myers Squibb is spinning off a fresh company armed with five autoimmune disease drugs and $300 million in Bain ...

“This shows that the TYK2 pathway continues to be a very important pathway for psoriasis pathogenesis and, therefore, a key pathway to target with our oral therapeutics.” ...

In addition, TYK2 degradation leads to superior inhibition of the Type 1 IFN pathway compared to TAK-2791, which is relevant to the treatment of interferonopathies.

So, what we see overall is that the TYK2 pathway is well defined and is the pathway that I think as a community we're converging on in terms of oral therapies for patients with psoriasis that ...

TYK2, however, is exclusively involved in regulating the immune response and plays an important role in activating pro-inflammatory pathways involved in diseases like psoriasis, mediating ...

Source: Krueger JG, et al. Clinical efficacy of TAK-279, a highly selective oral tyrosine kinase 2 (TYK2) inhibitor, is associated with modulation of disease and TYK2 pathway biomarkers in ...

As a non-receptor tyrosine kinase, TYK2 is a member of the JAK kinase family, which is an important kinase on the JAK-STAT signaling pathway and plays an important role in the pathogenesis of ...

TYK2’s role in the development of intracellular tau neurofibrillary tangles associated with neurodegeneration has been discovered. Researchers at Baylor College of Medicine (TX, USA) and collaborating ...