Uniform protein labeling in intact tissues is a challenge. An approach that allows antibodies to seep within organs could label proteins in millions of cells. Conventional protein-tagging methods, ...

Profiling the proteins that cells are making is a staple of studies in biology, neuroscience and related fields because the proteins a cell is expressing at a given moment can reflect the functions ...

Structural alignment in fibrous tissues like myocardium and tendons is a key biomarker of physiological integrity and ...

When there's a vexing problem to be solved, people sometimes offer metaphorical advice such as "stretching the mind" or engaging in "flexible" thinking, but in confronting a problem facing many ...

Clearing methods allow light to penetrate samples for imaging, although the method used can affect tissue permeability to molecular probes. Conventional labeling protocols involve the slow diffusion ...

A research team has established an optimized three-dimensional (3D) tissue-staining and observation technique based on existing tissue clearing technology. The study details how the new technique can ...

* Context. - The labeling of paraffin blocks and microscopic glass slides in the practice of surgical pathology varies from institution to institution and introduces ...

A new technology developed at MIT enables scientists to label proteins across millions of individual cells in fully intact 3D tissues with unprecedented speed, uniformity, and versatility. Using the ...

A mouse brain hemisphere stained with various cell type makers: neurons overall (cyan), and cells specifically involved with neurotransmitters dopamine (yellow) and acetylcholine (magenta). A new ...