In a study published in Advanced Materials, a research team developed an innovative bacterial cellulose (BC)-based hemostatic ...

Thrombin generation (TG) works by introducing a thrombin-specific chromogenic or fluorescent substrate to clotting plasma, permitting measurement of the activity of thrombin as a function of time.

How Well Do Direct Thrombin Inhibitors Work? This is a relatively new kind of drug. It was tested (before getting approval) against the drug warfarin, which for decades has been the go-to blood ...

Thrombin, which is an active form of prothrombin, is an allosteric enzyme controlled by the binding of sodium. 15,16 Sodium-bound thrombin (known as the fast form) is optimized for procoagulation ...

Panel A shows thrombin generation, and Panel B shows thrombin inhibition. Examples of the in vitro curves for thrombin generation and inhibition are also shown. Procoagulant factors are ...

Antithrombin, a plasma protein, has been reported to control thrombin activity by directly binding to thrombin, as well as to have an anti-inflammatory effect. However, the actual molecular ...

Engineering Thrombin for Selective Specificity toward Protein C and PAR1. Journal of Biological Chemistry, 2010; 285 (25): 19145 DOI: 10.1074/jbc.M110.119875 ...

Direct inhibition of thrombin may offer similar anticoagulant properties but also impact the underlying disease process. As we continue to gain experience and develop new DTIs, a new balance may ...

There are a number of direct thrombin inhibitors. The most common are as follows: 1. Lepirudin (Refludan) Intravenous administration only. Used for the treatment of HIT (heparin induced ...