Tau protein is a microtubule-associated protein, widely present in the central nervous system. It plays a key role in maintaining and regulating the structure and function of neurons.

To confirm the significance of tyrosine 29 phosphorylation in the development of NFTs, mice received mRNA via infection with a viral vector, encoding either a pathogenic tau variant or a double mutant ...

While much research related to Alzheimer’s disease has concentrated on identifying ways to reduce the buildup of amyloid plaques — which form when sticky protein fragments known as amyloid beta ...

Source Reference: Islam T, et al "Phospho-tau serine-262 and serine-356 as biomarkers of pre-tangle soluble tau assemblies in Alzheimer's disease" Nat Med 2025; DOI: 10.1038/s41591-024-03400-0.

Researchers have used an experimental drug to slow the phosphorylation of tau, which causes it to aggregate into neuron-damaging tangles in Alzheimer's disease Depositphotos View 1 Images ...

To realize the specific dephosphorylation of tau, Jian-Zhi Wang and her teams have conceptualized a strategy, Dephosphorylation-targeting chimera (DEPTAC), which is capable of specifically ...

Conventional small-molecule drugs for reducing pTau include phosphatase activators of PP2A, and kinase inhibitors of GSK3β, CDK5, etc., as well as active or passive immunotherapies targeting pTau ...

Nonetheless, the study’s findings suggest that tau phosphorylation isn’t inherently harmful. Indeed, during brain development, it’s vital.

Several therapies have been developed to specifically target tau phosphorylation in AD. Memantine, for example, enhances PP2A activity, whereas sodium selenate reduces tau phosphorylation.

The researchers assessed 405 samples from DIAD mutation carriers, representing four tau sites, T181, S202, T205 and T217, and compared them with 639 CSF samples from 234 cross-sectional ...