This study aimed to critically appraise the current level of economic evidence available for thiopurine S-methyltransferase (TPMT) testing of thiopurine drugs, such as azathioprine. Six economic ...

Mayo Clinic researchers found that a gene variant, the TPMT∗8 allele, is associated with reduced metabolism of the thiopurine class of drugs. TPMT∗8 is relatively common in individuals of African or ...

"But we also found that TPMT variants do not completely explain mercaptopurine intolerance, particularly in patients of East Asian ancestry." Six percent of the patients in this study who required ...

Background. A 50-year-old man who had received a simultaneous pancreas and kidney transplant 9 years earlier developed pancytopenia 3 weeks after starting azathioprine therapy to treat worsening ...

Personalized Medicine. 2009;6(1):103-113. The six economic evaluations were all retrospective modeling studies that synthesized existing clinical and cost data supplemented by expert opinion where ...