It's a notable set of findings, not least because it suggests a way that glycogen and tau aggregation could be tackled in the brain. The researchers also developed a drug based around the 8-Br-cAMP ...

When glycogen cannot be broken down, neurons cannot manage oxidative stress, worsening neurodegeneration, however, increasing enzyme glycogen phosphorylase (GlyP) clears excess sugar and stops tau ...

About INV-101 INV-101 is a first-in-class oral small molecule that selectively inhibits glycogen phosphorylase, disrupting the metabolic reprogramming of pro-inflammatory immune cells.

Rita Basu holds the Endowed Professorship in Diabetes Science in the UAB Department of Medicine Division of Endocrinology, Diabetes, and Metabolism and is a senior scientist in the UAB Comprehensive ...