More information: Wei Xu et al, Reprogramming aerobic metabolism mitigates Streptococcus pyogenes tissue damage in a mouse necrotizing skin infection model, Nature Communications (2025).

Zosurabalpin is able to destroy Gram-negative bacteria by jamming LPS molecules inside the bacteria, weakening its membrane. It is the first of its class of antibiotics, and the first new class of ...

Despite the rising need for new Gram-negative antibacterial agents due to resistant infections, no new class has been approved by the Food and Drug Administration (FDA) in over 50 years.

The bacterium, known as flesh-eating bacteria, has aggressively invaded the tissue (blue), causing extensive damage and destruction.