Figure 1: Domain architecture and cryo-EM structure of human Dicer. Figure 2: A pre-siRNA spans human Dicer between the cap and branch while a pre-miRNA binds the platform of the enzyme. The ...
Dicer is a multidomain enzyme that generates small RNAs for gene silencing in eukaryotes. Current understanding of Dicer structure is restricted to simple forms of the enzyme, whereas that of the ...
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