"The importance of deoxyribonucleic acid (DNA) within living cells is undisputed" (Watson & Crick, 1953). This opening sentence of James Watson and Francis Crick's second major paper, published ...

For example, if you feed linear nucleic acids to human cells, they will reject them. The reason behind this is that the cell membrane is negatively charged and the DNA is also negatively charged.

The paper, published in Nature-a collaboration between Rockefeller, Princeton University, and the Université libre de ...

Nucleic acid therapies offer targeted treatment for genetic diseases, but delivery remains a key hurdle. Explore how advances ...

Subtle differences in molecular structure can have a major impact on the performance of mRNA-based drugs. The findings open ...

A team from the Max-Planck-Institut für Kohlenforschung, Hokkaido University, and Osaka University has discovered that subtle ...

If you are studying nucleic acid structures in your lab, you may apply several methods to identify and characterize G4 structures and confirm their formation in your samples.

A peptide nucleic acid (turquoise backbone) can bind to a strand of DNA (orange backbone) if their nucleobase sequences are complementary. Credit: J. Am. Chem. Soc.

Researchers at the University of Oxford and Nanyang Technological University, Singapore (NTU Singapore) have uncovered the ...