BUFFALO, N.Y. – University at Buffalo research has identified how a misstep in the genesis of a key component of the kidney causes infantile cystinosis, a rare disease that significantly shortens the ...

These labeling studies allowed Barker and co-workers to monitor Lgr5 +ve cells as they participated in the formation of nephron tubules during kidney development (see image). "We succeeded in ...

This image, produced by a fluorescence microscope, shows a normal renal proximal tubule, the specific nephron segment in the kidney that is impaired in the rare disease infantile cystinosis.

Mouse kidney nephron progenitor cells (purple) forming the developing nephron tubules (yellow) of the kidney’s filtering units, the nephrons. (Image by Helena Bugacov/McMahon Lab)   ...

As tubule branching continues, they found that each additional branch caused a pulse of mechanical stress, which the team believes may constitute one of the signals for nephron formation.

Each nephron is made of a tubule and is responsible for 'cleaning' the blood by removing urea and excess water and mineral ions. The kidney works in a number of different stages: ...

The nephron has a renal tubule and dilated blind end like a funnel. This dilated funnel like part is called Bowman's Capsule. Each human kidney contains about 1 million filtering units called ...

Transcription factors AP-2α and AP-2β regulate distinct segments of the distal nephron in the mammalian kidney. Nature Communications, 2022; 13 (1) DOI: 10.1038/s41467-022-29644-3 ...

Each nephron is made of a tubule and is responsible for 'cleaning' the blood by removing urea, excess water and mineral ions. The kidney works in a number of different stages: ...