Rabies is notoriously difficult to treat once symptoms begin, and that challenge starts at the molecular level. Unlike many ...

The positive-stranded genomic RNA (gRNA) serves as a template for translating viral proteins and generating negative-stranded replication intermediates.

Replication of this kind involves the formation of a long chain of negative (-) strand RNAs, known as a concatemer. Each negative-strand RNA is a mirror image of the original, positive-strand genome.

To find out which parts of the hepatitis D virus genome interact with RNA polymerase II, Greco-Stewart et al. broke the genome down into three domains: a 213-nucleotide-long section corresponding ...

Transcription comprises a template-switching during the subgenomic negative-strand RNA synthesis to incorporate a replica of the leader sequence into the developing negative RNA.

The causative agent is rabies virus (RV), a negative-stranded RNA virus of the rhabdovirus family, which has a relatively simple, modular genome organization and encodes five structural proteins ...