A new type of drug, known as an anti-necrotic, could be the first drug ever approved to treat aging itself. The drug, which ...

A new type of drug is being tested and, if successful, it could become the first ever approved to slow or stop aging. The ...

Researchers reckon that 'anti-nectrotics' drugs could be a game-changer for the health sector as the medication could stop ...

A distinct signaling pathway called TNF-α drives the transformation of epithelial cells into aggressive tumor cells. During cancer progression, cells activate their own TNF-α program and become ...

A groundbreaking review in Current Molecular Pharmacology explores the dual roles of Tumor Necrosis Factor-alpha (TNFα) in ...

A cascade of cell necrosis begins in SRP-6-deficient animals exposed to a number of different stressors, including water, heat and lack of oxygen. In the case of water exposure, the SRP-6 knock ...

Dr. Ma adds, "Our results show that BB1 prevented the TNF-α increase in intestinal tight junction permeability via a toll-like receptor (TLR)-2 signal transduction pathway inhibition of NF-kB p50 ...

Using mouse models of CD, Cominelli and his team investigated the interaction between a class of proteins called tumor necrosis factor and receptors on the surface, called Fn14. Their goal was to see ...

Dr. Ma adds, "Our results show that BB1 prevented the TNF-α increase in intestinal tight junction permeability via a toll-like receptor (TLR)-2 signal transduction pathway inhibition of NF-kB p50 ...