The team looked at the impact of two Nav channel accessory subunits, the beta 1 and beta 3 subunits, on the interaction between lidocaine and ranolazine on Nav1.5-encoded channels.

He declined to speculate on when the drug might hit the market, however. Suzetrigine is an oral, small molecule that selectively inhibits voltage-gated sodium channel 1.8 (NaV 1.8).

New research explains how low levels of the electrolyte sodium in the blood can disrupt the timing of the heartbeat in patients taking widely used rhythm-control medications such as flecainide, which ...

Key Takeaways Halneuron, a NaV 1.7 sodium channel inhibitor, is being tested for chemotherapy-induced neuropathic pain, offering a potential opioid alternative. Previous trials showed Halneuron ...

Siteone Therapeutics Inc. has provided details on the discovery of highly selective, potent, state-independent inhibitors of Nav1.7, a nonopioid target for the potential treatment of pain. While prior ...

More information: Ayumi Sumino et al, Voltage sensors of a Na+ channel dissociate from the pore domain and form inter-channel dimers in the resting state, Nature Communications (2023).

Latigo Biotherapeutics Inc. and Lieber Institute Inc. have synthesized new methyl-substituted pyridine and pyridazine compounds acting as sodium channel protein type 10 subunit α (Nav1.8) channel ...

All of the sodium channels are closely related, and early research efforts found it difficult to target the channels that transmit pain signals without also hitting the other channels, Mulcahy ...

New research explains how low levels of the electrolyte sodium in the blood can disrupt the timing of the heartbeat in patients taking widely used rhythm-control medications such as flecainide, which ...