Multistep prostate carcinogenesis The light microscopic histologic appearance of prostates from control littermate, probasin-bcl-2, TRAMP, and BxT mice was evaluated at intervals ranging from 8 ...

The first reports of cancer stem cells suggested that only a very small subset of tumor cells can both self-renew and undergo differentiation. However, the development of new strains of mice for ...

It appears that CRC epigenetics will be the paradigm for multistep carcinogenesis, as CRC genetics has been for the past three decades. This review integrates recent data on epigenetic regulation of ...

The multistep carcinogenesis model suggests that well-differentiated thyroid cancer cells can transform into undifferentiated thyroid cancer cells The fetal cell carcinogenesis model postulates that ...