T cells are central to adaptive immunity, orchestrating targeted responses against infections and malignancies while forming a durable immunological memory. Memory T cells, particularly CD8+ subsets, ...

Scientists at UW Medicine, University of Washington, and their collaborators have pinpointed exactly when cytotoxic T lymphocytes form memories during infection. They also examined the epigenetic ...

Pre-wired ability in ‘resting’ T cells to remember past viral foes discovered, a promising breakthrough for targeted cancer therapies. A team of immunologists at the University of Massachusetts ...

Immune responses are largely memorized by terminally differentiated memory T cells, but the precise mechanism by which a relatively small number of cells can memorize a vast number of antigens has ...

Study uncovers a pathogenic subset of memory T-cells that promote tissue inflammation and highlights a potential target for treating nasal polyps and other inflammatory airway diseases. Study: ...

For some diseases, a few vaccine doses enable lifetime immunity. But influenza requires annual vaccines to maintain immunity. One reason is because lung T cells only live for a few months.

It has been 4 years since the start of the COVID-19 pandemic. SARS-CoV-2 has yet to be eradicated and new variants are continuously emerging. Despite the extensive immunization programs, breakthrough ...

COVID-19 vaccines elicit strong T-cell responses, but clonal-resolution analyses of these responses have not previously been performed. To address this gap, a team of researchers investigated the T- ...

Effect of heterozygosity loss of HLA-I on immune evasion and promotion of non-small cell lung cancer brain metastasis and immunotherapy resistance. This is an ASCO Meeting Abstract from the ASCO ...

T-cell redirection therapy using chimeric antigen receptor (CAR) T cells and/or bispecific antibody (BsAb) has been established and become a promising treatment strategy for relapsed/refractory B-cell ...